Antimicrobial Peptide-Antibiotic Conjugates

The second project aims to prepare antimicrobial peptide-antibiotic conjugates to contend with multi-drug-resistant bacteria by using combinations of conventional antibiotics with AMPs. The research team will use different linker and conjugation approaches to enhance the bioactivity of AMPs and investigate their mode of action. These approaches can be achieved through total solid-phase synthesis or in solution via a variety of bimolecular reactions.