Antimicrobial Peptide Multimerization

This project involves the multimerization of AMPs to confer improved properties on other AMPs by enhancing their cationic charge and improving their interaction with bacterial membranes. The research team has developed a series of new dimeric AMPs to target WHO priority critical Gram-negative bacterial pathogens, such as A. baumannii and its multi-drug-resistant strain. They plan to prepare analogues of selected peptides and screen several bifunctional linkers to determine the general applicability of this method.