1. RETURN TO ISSUEPREVNOTENEXTWater-Compatible Iminium Activation: Highly Enantioselective Organocatalytic Michael Addition of Malonates to α,β-Unsaturated Enones

Written By Evon Yu

Abstract:

The highly enantioselective Michael addition of malonates to α,β-unsaturated ketones in water was reported to be catalyzed by a primary−secondary diamine catalyst containing a long alkyl chain. This asymmetric Michael addition process was found to be effective for a variety of α,β-unsaturated ketones.

Mao, Z.; Jia, Y.; Li, W.; Wang, R.* (2010): Water-compatible iminium activation: highly enantioselective organocatalytic Michael addition of malonates to alpha,beta-unsaturated enones. J. Org. Chem. 75, 7428-7430, DOI: 10.1021/jo101188m.

Evon Yu
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