20. Recent Applications of Aggregation Induced Emission Probes for Antimicrobial Peptide Studies

Abstract:

Antimicrobial peptides (AMPs) are being intensively investigated as they are considered promising alternatives to antibiotics where their clinical efficacy is dwindling due to the emergence of antimicrobial resistance (AMR). Accompanying with the development of AMPs, a number of fluorescent probes have been developed to facilitate the understanding the modes of action of AMPs. These probes have been used to monitor the binding process, determine the working mechanism and evaluate the antimicrobial properties of AMPs. In particular, with the recent advance of aggregation-induced emission (AIE) fluorophores, that show many advantageous properties over traditional probes, there is an increasing research interest in using AIE probes for AMP studies. In this review, we give an overview of AMP development, highlight the recent progress of using fluorescence probes in particularly AIE probes in the AMP field and propose the future perspective of developing potent antimicrobial agents to combat AMR.

Luu, T.; Li, W.*; O’Brien-Simpson; N. M.; Hong, Y.* (2021), Recent applications of aggregation induced emission probes for antimicrobial peptide studies, Chem.: Asian J. 16, 1027, DOI 10.1002/asia.202100102