29. Peptide Multimerization as Leads for Therapeutic Development

Abstract:

Multimerization of peptide structures has been a logical evolution in their development as potential therapeutic molecules. The multivalent properties of these assemblies have attracted much attention from researchers in the past and the development of more complex branching dendrimeric structures, with a wide array of biocompatible building blocks is revealing previously unseen properties and activities. These branching multimer and dendrimer structures can induce greater effect on cellular targets than monomeric forms and act as potent antimicrobials, potential vaccine alternatives and promising candidates in biomedical imaging and drug delivery applications. This review aims to outline the chemical synthetic innovations for the development of these highly complex structures and highlight the extensive capabilities of these molecules to rival those of natural biomolecules.

Sheard D.#, Li, W.#*, O’Brien-Simpson; N. M., Separovic, F.*; Wade, D. J. (2022), Chemical peptide multimerization as leads for therapeutic development, Biologics, 2(1), 15-44; DOI: 10.3390/biologics2010002