WELCOME TO THE
RESEARCH
Dr. Wenyi Li is a Senior Lecturer and NHMRC Investigator (Emerging Leadership Level 1) in the development of antimicrobials to combat nosocomial infections by using his chemical biology expertise and skillset at Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia. By fostering an active collaborative research network, Dr Li has obtained several outstanding successful grants of a total of >$2 million, including 1 NHMRC Investigator EL1 grant, CIA Ramaciotti Health Investment Grant and 1 CIE NHMRC Ideas Grant.
Fostering innovation through cutting-edge research
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“Dedicated to advancing chemical biology and combating infections through collaboration.”
— Dr. Wenyi Li
Contact
Address
La Trobe Institute for Molecular Science
Department of Biochemistry and Chemistry
La Trobe University | Bundoora, Victoria | 3086 | Australia
Email
wenyi.li@latrobe.edu.au
Phone
+61 (03) 9479 6336
Site-selective chemical modifications of proteins have emerged as a potent technology in chemical biology, materials science, and medicine, facilitating precise manipulation of proteins with tailored functionalities for basic biology research and developing innovative therapeutics. Compared to traditional recombinant expression methods, one of the prominent advantages of chemical protein modification lies in its capacity to decorate proteins with a wide range of functional moieties, including non-genetically encoded ones, enabling the generation of novel protein conjugates with enhanced or previously unexplored properties. Among these, approaches for dual or multiple protein modifications are increasingly garnering attention, as it has been found that single modifications of proteins are inadequate to meet current demands. Therefore, in light of the rapid developments in this field, this review provides a timely and comprehensive overview of the latest advancements in chemical and biological approaches for protein dual functionalization. It further discusses their advantages, limitations, and potential future directions in this relatively nascent area.